Bekijk dit rapport over Koop Dimethyltryptamine
Bekijk dit rapport over Koop Dimethyltryptamine
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In een boek uit 1997 het hij samen met bestaan dame en collega Ann Shulgin schreef, staat ons beschrijving opgenomen met bestaan persoonlijke expertise betreffende geïnhaleerde dimethyltryptamine, verklarend DMT.
It was at this point that I began to wonder if I was getting in aan my head with this research."[36]
In order to advance, however, regulatory blockades to hallucinogen onderzoek must be removed. Progress in hallucinogen research in these areas has been slowed due to over-regulation. For at least the hinder 50 years, onderzoek on DMT and other hallucinogens has been impeded in the United States by passage of the Congressional Amendment ofwel 1965 and the Controlled Substances Act of 1970 by the United States Congress that classified DMT and other major hallucinogens as Schedule-I substances. Given the endogenous nature of DMT, it deserves a special status for future research.
Behalve de plantaardige bronnen aangaande DMT, kan zijn er een variant afkomstig van een huid met bepaalde kikkers, vertrouwd als 5-MeO-DMT. Die verbinding staat bekend om bestaan intense en supersnelle psychedelische ervaringen, die geraken beschreven wanneer een directe toegang tot de essentie over de DMT-realm.
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. Using dialyzed, centrifuged whole-brain homogenate supernatant from rats and humans, these same researchers determined that the rate of synthesis ofwel DMT from TA was 350 and 450 pmol/g/hr and 250 and 360 pmol/g/h, using NMT as substrate, in these tissues, respectively. In 1973, Saavedra et al. characterized a nonspecific N-methyltransferase in rat and human brain, reporting a Km for the enzyme of 28 uM for TA as the substrate in rat brain. The highest enzyme activity in human brain was found in the subcortical layers of the fronto-parietal and temporal lobes and the cortical layers of the frontal parietal lobe.
Perhaps the true “hallucinogen” receptor has already been discovered and is simply mislabeled as being one of the many 5-HT receptors. Perhaps it is their interaction with many receptors and their complex functional connectivity that produces the observed effects (Ray, 2010; Halberstadt and Geyer, 2011). Indeed, the gegevens suggest that DMT is both endogenous and possesses the properties of a neurotransmitter (see below). Studies have clearly shown that it binds with respectable affinity to the 5-HT2A receptor as well as other members ofwel the serotonin family of receptors and elicits biochemical and physiological activity that can be correlated, to some degree, with such binding.
En uit dit onderzoek bleek het de ontmoeting betreffende de entiteit veelal visueel en telepathisch is. Een meeste veel voorkomende beschrijvingen van een entiteit zijn ons ‘wezen’, een ‘gids’, ons ‘geest’ of ons ‘buitenaards wezen’. Maar ze mogen iedere gedaante aannemen – sommigen zijn onzinnig of beangstigend. Terrance McKenna, een etnobotanicus en psychedelica-onderzoeker, beschreef de entiteiten welke hij ontmoette mits “machine-elfen”.
Similar data have recently been presented for a tetra deutero-5-MeO-DMT (Halberstadt et alang., 2012) and the authors reached a similar conclusion; these results demonstrate that deuterated tryptamines may be useful in behavioral and pharmacological studies to mimic the effects ofwel tryptamine/MAOI combinations, but without the MAOI. While the synthesis ofwel deuterated analogs may be more expensive initially, newer methods for such synthesis (Brandt et weet., 2008) may overcome these concerns. Furthermore, the pharmacological properties ofwel D4DMT may render it orally active. Such a possibility has yet to be explored. It is also possible that oral administration and kinetic isotope effect inhibition of metabolism may prolong the effects of a deuterated analog sufficiently to also be of use in imaging studies.
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At present, the data arguing for the use ofwel DMT as a therapeutic, particularly via administration, is thin. The claimed therapeutic effects for DMT in combination with harmala MAOIs as in ayahuasca or pharmahuasca (Ott, 1999) is of interest but presents a complex data set that prevents an understanding of the contribution ofwel each component. To further study DMT without the effects ofwel an MAOI, research should pursue whether or not D4DMT is orally active, as previously noted, which would enhance the opportunities to examine its potential as a therapeutic.
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Van een rijke geschiedenis en verschillende bronnen tot een Koop Dimethyltryptamine diepgaande spirituele rituelen en transcendentale ervaringen, DMT bezit ons blijvende impact gehad op de menselijke cultuur en het spirituele landschap.
Vanwege een orale hoeveelheid dien men verder verdere benutten teneinde gelijk effect te krijgen in vergelijking met de nasale dosering. Een lage dosis bij oraal behandeling is gezien tussen een 75mg en 150mg